https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48722 Wed 29 Mar 2023 16:36:36 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54489 Wed 28 Feb 2024 16:31:52 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49974 Wed 28 Feb 2024 16:14:53 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53244 Wed 28 Feb 2024 15:33:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54319 Wed 28 Feb 2024 15:02:19 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50396 Wed 28 Feb 2024 15:00:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53417 Wed 28 Feb 2024 14:49:12 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45066 Wed 26 Oct 2022 17:37:36 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45050 Wed 26 Oct 2022 16:03:47 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45171 Wed 26 Oct 2022 14:18:49 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45111 2) test was used to identify if there was any association with maternal high-risk fertility behaviours and use of healthcare services. A multivariate logistic regression model was used to determine the effects of fertility behaviors and healthcare usage on the occurrence of U5M adjusting with confounders. Results: U5M declined from 82.5 to 41.0 per 1000 livebirths during 1994–2014 and is projected to further reduce to 17.6 per 1000 livebirths by 2030. The study identified a noticeable regional variation in U5M with maternal high-risk fertility behaviours including age at birth <18 years (aOR: 1.84, 95% CI: 1.23–2.76) and birth interval <24 months (aOR: 1.56, 95% CI: 1.02–2.37) found to be significant determinants. There was a 39–53% decline in this rate of mortality among women that had used antenatal care services at least four times (aOR, 0.51, 95% CI: 0.27–0.97), delivery care (aOR, 0.47, 95% CI: 0.24–0.95), and had received postnatal care (aOR, 0.61, 95% CI: 0.41–0.91) in their last birth. Cesarean section was found to be associated with a 51% reduction in U5M (aOR, 0.49, 95% CI: 0.29–0.82) compared to its non-use. Conclusion: The Sustainable Development Goals require a U5M rate of 25 per 1000 livebirths to be achieved by 2030. This study suggests that with the current trend of reduction, Bangladesh will achieve this target before the deadline. This study also found that maternal high-risk fertility behaviours and non-use of maternal healthcare services are very prevalent in some regions of Bangladesh and have increased the occurrence of U5M in those areas. This suggests therefore, that policies and programmes designed to reduce the pregnancy rates of women that are at risk and to encourage an increase in the use of maternal healthcare services are needed.]]> Wed 26 Oct 2022 12:45:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38348 Wed 24 May 2023 12:55:56 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53234 Wed 20 Mar 2024 15:32:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52706 Wed 20 Mar 2024 14:49:32 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49893 A and I157T. Predictors of survival were determined among CHEK2 pathogenic variant carriers using the Cox proportional hazards model. The median follow-up was 17.5 years. Covariates included age (≤60; >61 years), sex (female; male), clinical characteristics (stage: TNM, grade, histopathological type), smoking status (non-smoking; smoking) and cancer family history (negative; positive). Results: We found no impact of CHEK2 mutations on bladder or kidney cancer survival. However, we observed a possible increased survival in the subgroup of patients with stage T1 bladder cancer with CHEK2 mutations but this did not meet statistical significance (HR = 0.14; 95% CI 0.02–1.04; p = 0.055). Moreover, we observed that the missense mutations were more frequent in the low grade invasive bladder cancer patient group (OR = 7.9; 95% CI 1.50–42.1; p = 0.04) and in patients with bladder cancer with stage Ta (OR = 2.4; 95% CI 1.30–4.55; p = 0.006). The different results where missense mutations occurs less often we observed among patients with high grade invasive bladder cancer (OR = 0.12; 95% CI 0.02–0.66; p = 0.04) and those with stage T1 disease (OR = 0.2; 95% CI 0.07–0.76; p = 0.01). Our investigations revealed that any mutation in CHEK2 occurs more often among patients with stage Ta bladder cancer (OR = 2.0; 95% CI 1.19–3.47; p = 0.01) and less often in patients with stage T1 disease (OR = 0.31; 95% CI 0.12–0.78; p = 0.01). In the kidney cancer patients, truncating mutations were present more often in the group with clear cell carcinoma GII (OR = 8.0; 95% CI 0.95–67.7; p = 0.05). The 10-year survival for all CHEK2 mutation carriers with bladder cancer was 33% and for non-carriers 11% (p = 0.15). The 10-year survival for CHEK2 mutation carriers with kidney cancer 34% and for non-carriers 20% (p = 0.5). Conclusion: CHEK2 mutations were not associated with any change in bladder or kidney cancer survival regardless of their age, sex, smoking status and family history. We observed a potentially protective effect of CHEK2 mutations on survival for patients with stage T1 bladder cancer. CHEK2 missense mutations were more common among patients with low grade invasive bladder cancer and in patients with stage Ta diease. The frequencies of the I157T CHEK2 pathogenic variant were less in patients with high grade invasive bladder cancer and those with stage T1 disease. Among patients with bladder cancer with stage Ta disease, the OR for any mutation in CHEK2 was 2.0 but for those with stage T1 disease, the OR was 0.3. We observed truncating CHEK2 mutations were associated with kidney cancer patients with GII clear cell carcinoma.]]> Wed 14 Jun 2023 17:10:17 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47192 Wed 13 Mar 2024 19:10:29 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43916 Wed 13 Mar 2024 08:57:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45437 Wed 13 Mar 2024 08:08:20 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44376 p < 0.05), but not obviously different in Hubei province (p > 0.05). The CCOPSPTT had significant correlation with socio-economic determinants (GDP and population), DW, climate and time after the outbreak of COVID-19 outside Hubei province (p < 0.05), while was only significantly related with GDP in Hubei province (p < 0.05). The DOPSPTT showed significant correlation with socio-economic determinants, DW, time and CCOPSPTT outside Hubei province (p < 0.05), while was significantly correlated with GDP and CCOPSPTT in Hubei province (p < 0.05). Compared with other factors, socio-economic determinants have the largest relative contribution to variance of CCOPSPTT in all studied cities (> 78%). The difference of DOPSPTT among cities was mainly affected by CCOPSPTT. Our results showed that influences of city types on the confirmed cases and death differed between Hubei and other provinces. Socio-economic determinants, especially GDP, have higher impact on the change of COVID-19 transmission compared with other factors.]]> Wed 12 Oct 2022 11:14:01 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52453 Wed 11 Oct 2023 15:07:47 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52461 Wed 11 Oct 2023 15:01:35 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52416 Wed 11 Oct 2023 11:59:18 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37444 Wed 10 Nov 2021 15:05:39 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53725 Wed 10 Jan 2024 11:23:54 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55113 Wed 10 Apr 2024 15:17:20 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38938 Wed 09 Mar 2022 15:58:36 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51200 Wed 07 Feb 2024 14:57:45 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43966 Wed 05 Oct 2022 14:15:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50362 Wed 03 Apr 2024 15:56:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49736 Tue 30 May 2023 13:37:59 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52017 Tue 26 Sep 2023 12:11:09 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50425 Tue 25 Jul 2023 18:48:29 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50407 Tue 25 Jul 2023 17:23:12 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51131 Tue 22 Aug 2023 15:58:44 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54333 1.8. The primary outcome was good functional outcome at 90 days, defined as a modified Rankin Scale (mRS) score 0-2. follow-up infarct volume, core expansion and penumbral salvage volumes were secondary outcomes. Of 572 anterior circulation EVT patients, CTP source image data required to generate objective maps were available in 170, and a Target Mismatch was present in 151 (89%). The rate of 90-day good functional outcome was similar between Target Mismatch (53%) and Large Core Non-Mismatch groups (46%, p = 0.629). Median follow-up infarct volume in the Large Core Non-Mismatch group (104ml [IQR 25ml-189ml]) was larger than that in the Target Mismatch patients (16ml [8ml-47ml], p<0.001). Despite a lack of formal CTP selection criteria, the majority of patients treated at our centres had a Target Mismatch. Patients without Target Mismatch had larger follow-up infarct volumes, but the functional recovery rate was similar to that in Target Mismatch patients. Infarct volumes should be included as objective assessment criteria in the evaluation of the efficacy of EVT in non-Target Mismatch patients.]]> Tue 20 Feb 2024 16:05:37 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52576 Tue 17 Oct 2023 15:48:32 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41918 Tue 16 Aug 2022 14:24:31 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55152 Tue 16 Apr 2024 15:23:09 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55148 Tue 16 Apr 2024 15:16:07 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48302 Tue 14 Mar 2023 14:20:04 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48298 Tue 14 Mar 2023 13:17:45 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48287 Tue 14 Mar 2023 11:12:00 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54249 Tue 13 Feb 2024 13:26:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51638 Tue 12 Sep 2023 20:15:14 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44309 Tue 11 Oct 2022 16:12:27 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38924 Tue 08 Mar 2022 11:01:15 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51432 Tue 05 Sep 2023 17:57:19 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43853 Tue 04 Oct 2022 12:00:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38093 'Health Workplace Framework and Model') which aims to provide a sustained approach to wellness in the workplace. This paper presents baseline findings from a pilot study that aimed to implement RESHAPE at three mine sites in NSW, Australia, and investigates the issue of overweight and obesity in the coal mining industry. Across three mine sites, 949 coal miners were examined cross-sectionally on a range of workplace, wellness, health, diet, and exercise factors using a paper-based survey. This was a predominantly male sample (90.4%) with the majority (59.2%) of participants aged 25-44 years. Selfreported height and weight measures indicated that less than 20 percent (18.9%) of participants were in a healthy BMI range, while there were effectively equal numbers of overweight (40.9%) and obese (39.1%) participants. Only 3.5% of participants met the daily recommendation for vegetables (5 serves) and shift-workers had greater association with elevated BMI compared to non-shift workers (B = 1.21, 95% CI: 0.23, 2.20, p = 0.016). Poor nutrition is likely to be a key component in elevated levels of overweight and obesity within this industry, with workplace factors compounding challenges workers face in implementing health behavior change. Future studies would benefit from assessing diet and physical activity knowledge in relation to recommendations and serving sizes.]]> Tue 03 Aug 2021 18:29:05 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52117 Thu 28 Sep 2023 15:03:18 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44822 Thu 27 Oct 2022 09:51:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52773 Thu 26 Oct 2023 14:54:24 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37950 Thu 25 Nov 2021 12:29:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53982 Thu 25 Jan 2024 12:57:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51056 Thu 17 Aug 2023 10:19:58 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54289 Thu 15 Feb 2024 14:45:40 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38512 Thu 14 Oct 2021 09:46:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37577 Thu 14 Apr 2022 11:03:01 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37244 Thu 09 Dec 2021 11:03:26 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40163 Thu 06 Jul 2023 10:57:56 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38559 Thu 04 Nov 2021 11:03:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38535 Mon 29 Jan 2024 17:49:44 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50392 0.49), but not with autism or the less common adult disorders (schizophrenia, bipolar disorder, or eating disorders) (rG < 0.01). Importantly, the total psychiatric problem score also showed at least a moderate genetic correlation with intelligence, educational attainment, wellbeing, smoking, and body fat (rG > 0.29). The results suggest that many common genetic variants are associated with childhood psychiatric symptoms and related phenotypes in general instead of with specific symptoms. Further research is needed to establish causality and pleiotropic mechanisms between related traits.]]> Mon 24 Jul 2023 14:40:41 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52709 19.8 km·h-1] and average acceleration. Linear mixed models and effect sizes identified differences between competition levels. No differences existed between competition levels for any total match physical performance metric. Peak total and high-speed distances demands were similar between competitions for all moving average durations. Interestingly, peak average acceleration demands were lower (SMD = 0.63–0.69) in the youth players across all moving average durations. The data suggest that the development of acceleration and repeat effort capacities is crucial in youth players for them to transition into professional competition.]]> Mon 23 Oct 2023 16:12:48 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53261 Mon 20 Nov 2023 12:14:28 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43419 Mon 19 Sep 2022 08:32:03 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40749 0.05) and type of services (β = 0.025; p>0.05) had a positive moderating effect on the relationship between health system structure and outcome but were not significant. Conclusion: Improvements to mental health system structure and the process could promote the quality of services as experienced by consumers. Government stakeholders are encouraged to accordingly strengthen health systems with the aim of improving the mental health outcomes for consumers.]]> Mon 18 Jul 2022 13:33:26 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50308 Mon 17 Jul 2023 13:46:00 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39141 Mon 16 May 2022 15:36:53 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54177 Mon 12 Feb 2024 10:03:02 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54773 Mon 11 Mar 2024 15:08:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49835 Mon 05 Jun 2023 13:52:33 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51405 Mon 04 Sep 2023 14:53:07 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51392 Mon 04 Sep 2023 13:47:27 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40057 Mon 04 Jul 2022 15:12:41 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50113 Mon 03 Jul 2023 14:28:41 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38067 Mon 02 Aug 2021 12:26:57 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45471 2: 82⋅3%), and current cigarette use had over two times the risk (ARR 2⋅56 (95% CI: 1⋅61, 4⋅07; p<0⋅001, I²: 77⋅3%) at follow up. Among current ENDS/ENNDS users, there was a significant association with ever (ARR 2⋅63 (95% CI: 1⋅94, 3⋅57; p<0⋅001, I²: 21⋅2%)), but not current cigarette use (ARR 1⋅88 (95% CI: 0⋅34, 10⋅30; p = 0⋅47, I²: 0%)) at follow up. For other tobacco use, ARR ranged between 1⋅55 (95% CI 1⋅07, 2⋅23) and 8⋅32 (95% CI: 1⋅20, 57⋅04) for waterpipe and pipes, respectively. Additionally, two studies examined the use of ENNDS (non-nicotine devices) and found a pooled adjusted RR of 2⋅56 (95% CI: 0⋅47, 13⋅94, p = 0.035). Conclusion: There is an urgent need for policies that regulate the availability, accessibility, and marketing of ENDS/ENNDS to children and adolescents. Governments should also consider adopting policies to prevent ENDS/ENNDS uptake and use in children and adolescents, up to and including a ban for this group.]]> Fri 28 Oct 2022 14:49:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45409 Fri 28 Oct 2022 14:36:32 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45449 Fri 28 Oct 2022 14:15:35 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52812 in vivo and validated which of these are likely to arise primarily from Sertoli cells based on relevant mouse testis RNASeq datasets. We used a different, but complementary, approach to identify Sertoli cell-enriched proteins in human TIF, taking advantage of high-quality human testis genomic, proteomic and immunohistochemical datasets. We identified a total of 47 and 40 Sertoli cell-enriched proteins in mouse and human TIF, respectively, including 15 proteins that are conserved in both species. Proteins with potential roles in angiogenesis, the regulation of Leydig cells or steroidogenesis, and immune cell regulation were identified. The data suggests that some of these proteins are secreted, but that Sertoli cells also deposit specific proteins into TIF via the release of extracellular vesicles. In conclusion, we have identified novel Sertoli cell-enriched proteins in TIF that are candidates for regulating somatic cell-cell communication and testis function.]]> Fri 27 Oct 2023 15:56:20 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52793 Fri 27 Oct 2023 14:08:39 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52789 Fri 27 Oct 2023 10:22:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48639 19 (OR 2.48; 95% CI 1.44, 4.28), previous running injury (OR 1.95; 95% CI 1.31, 2.91), vaginal delivery (OR 1.63; 95% CI 1.06, 2.50), incontinence (OR 1.95; 95% CI 1.31, 2.84) and <6.8 hours of sleep on average per night (OR 1.89; 95% CI 1.28, 2.78). Having ≥ 4 risk factors increased the probability of having running-related pain to 61.2%. Conclusion: The results of this study provide a deeper understanding of the risk factors for running-related pain in postpartum runners. With this information, clinicians can monitor and educate postpartum runners initiating or returning to running. Education could include details of risk factors, combinations of factors for pain and strategies to mitigate risks. Coaches can adapt running workload accounting for fatigue and sleep fluctuations to optimize recovery and performance. Future longitudinal studies that follow asymptomatic postpartum women returning to running after childbirth over time should be performed to validate these findings.]]> Fri 24 Mar 2023 13:23:41 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51952 Fri 22 Sep 2023 17:06:03 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51950 Fri 22 Sep 2023 17:04:13 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53143 10 years and did not use an interpreter, had similar risk of term-LBW but 43% (aOR 1.43, 95% CI 1.14–1.78) higher risk of spontaneous PTB than the Australian-born women. Conclusion: Acculturation is an important factor to consider when providing antenatal care to prevent PTB and LBW in migrants. Acculturation may reduce the risk of term-LBW but, conversely, may increase the risk of spontaneous PTB in migrant women residing in Western Australia. However, the effect may vary by ethnicity and warrants further investigation to fully understand the processes involved.]]> Fri 17 Nov 2023 11:50:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39719 Fri 17 Jun 2022 17:31:03 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51707 Fri 15 Sep 2023 14:09:33 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40166 50% among nine studies. Among underweight women, the percentage of women who gained inadequate gestational weight ranged from 67% to 98%. Only two studies were included in the meta-analyses to evaluate the association of gestational weight gain with pre-eclampsia and macrosomia. No difference was observed among women who gained inadequate and adequate gestational weight regarding experiencing pre-eclampsia (RR, 0.71; 95% CI: 0.22, 2.28, P = 0.57). Excessive gestational weight gain was not significantly associated with macrosomia compared to adequate weight gain (RR, 0.68; 95% CI: 0.38, 1.22, P = 0.20). Conclusion: A substantial proportion of sub-Saharan African women gain inadequate gestational weight particularly high among underweight women. Future interventions would need to design effective pre-pregnancy weight management strategies.]]> Fri 15 Jul 2022 10:39:18 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40089 p<0.0001), smoking (p<0.0001) and unknown stage (p = 0.002). There was no evidence of differences by year of diagnosis or sex (both p>0.50). For 465 cases diagnosed 2014–2015, 29% had subsidised molecular testing for targeted therapy/immunotherapy and 4% had subsidised targeted therapies. Conclusions: Lung cancer healthcare costs are strongly associated with survival-related factors. Costs appeared stable over the period 2006–2013. This study provides a framework for evaluating the health/economic impact of introducing lung cancer screening and other interventions in Australia.]]> Fri 15 Jul 2022 10:04:25 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38491 Fri 12 Nov 2021 12:50:35 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49424 Fri 12 May 2023 15:09:21 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39508 Fri 10 Jun 2022 15:14:28 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54705 Fri 08 Mar 2024 12:15:09 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38119 0.003). Conclusions: Married women, unemployed and those with no formal education are less likely to participate in CC screening. The study details significant barriers to cervical cancer screening uptake in Ghana. It is recommended that the Ghana health services should develop appropriate, culturally tailored educational materials to inform individuals with no formal education through health campaigns in schools, churches and communities to enhance CC screening uptake.]]> Fri 03 Sep 2021 10:06:27 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38486 Fri 03 Dec 2021 15:17:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49785 10,000 U/L)]. The odds of (mild or severe) myotoxicity was lower in patients that received early antivenom (within 6 hours post-bite) compared to those that received late or no antivenom (odd ratio was 0.186; 95% confidence interval, 0.052–0.664). A population pharmacokinetic-pharmacodynamic (PKPD) model was developed to describe the relationship between the time course of venom (a mixture of toxins) and effect (elevated CK). In addition, a kinetic-pharmacodynamic (KPD) model was developed to describe the relationship between time course of a theoretical toxin and effect. Model development and parameter estimation was performed using NONMEM v7.3. No single set of parameter values from either the PKPD or KPD models were found that could accurately describe the time course of different levels of severity of myotoxicity. The predicted theoretical toxin half-life from the KPD model was 11 ± 3.9 hours compared to the half-life of venom of 5.3 ± 0.36 hours. This indicates that the putative causative toxin’s concentration-time profile does not parallel that of venom. Conclusion: Early antivenom administration reduces the incidence of myotoxicity. The venom concentration profile does not appear to be the driver for myotoxicity following envenomation. Additional factors that affect the sensitivity of the patient to snake venom/toxins must be explored to understand the relationship with myotoxicity.]]> Fri 02 Jun 2023 17:21:37 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51361 Fri 01 Sep 2023 13:41:53 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51335 Fri 01 Sep 2023 10:18:03 AEST ]]>